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Protein Coding Gene : Lbh limb-bud and heart

Primary Identifier  MGI:1925139 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  77889
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Involved in several processes, including negative regulation of intracellular estrogen receptor signaling pathway; positive regulation of mammary stem cell proliferation; and positive regulation of somatic stem cell division. Acts upstream of or within positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including gut; heart; limb bud; mesendoderm; and nervous system. Orthologous to human LBH (LBH regulator of WNT signaling pathway).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired mammary gland development and decreased litter size. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 6720416L16 gene,
  • limb-bud and heart,
  • Lbh,
  • MGI:1923995,
  • 6720416L16Rik,
  • 1810009F10Rik,
  • RIKEN cDNA 1810009F10 gene

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Canonical gene --> CDSs in specific strains.

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Canonical gene --> Transcripts in specific strains.

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