| Primary Identifier | IPR037562 | Type | Family |
| Short Name | Complement_C5 |
| description | This entry represents complement factor 5 (C5; MEROPS identifier I39.952). C5 is a component of the lytic complex consisting of factors C5-C9 which attacks bacterial cell membranes. C5 is synthesized as a precursor and is activated by a C5 convertase. The anaphylatoxin C5a is released and is a mediator of local inflammation. C5a is also a chemokine, directing polymorphonuclear leukocytes to the site of infammation. C5a binds to the receptor C5AR1, which results in intracellular calcium release, smooth muscle contraction, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes []. The tertiary structure of C5 has been solved and the fold is similar to that of complement C3 and the peptidase inhibitor alpha2-macroglobulin []. |
