| Primary Identifier | MGI:3718047 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Hmgcr-MAPT)23Brio |
| Strain of Origin | (C57BL/6J x CBA)F2 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The cDNA encoding the three-repeat human fetal tau (MAPT) protein (shortest human isoform) without the N-terminal insert was inserted after the mouse Hmgcr promoter region, exon 1 (not translated) and major intron 1, in the pHMG vector. The construct was microinjected into (C57BL/6J x CBA)F2 fertilized embryos. Line 23 was established. Human tau (MAPT) protein is detected in cell bodies and dendrites of neurons in many brain areas in adult animals with Western blots. |
