| First Author | Forman BM | Year | 1994 |
| Journal | Mol Endocrinol | Volume | 8 |
| Issue | 9 | Pages | 1253-61 |
| PubMed ID | 7838158 | Mgi Jnum | J:23754 |
| Mgi Id | MGI:71445 | Doi | 10.1210/mend.8.9.7838158 |
| Citation | Forman BM, et al. (1994) Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors. Mol Endocrinol 8(9):1253-61 |
| abstractText | We have cloned Rev-erb beta, a novel isoform of the Rev-erb alpha orphan nuclear receptor. The DNA binding domains of Rev-erb alpha and beta are highly related to each other and to the retinoic acid related orphan receptor (ROR)/RZR subfamily of nuclear receptors. Indeed, we find that all three receptors bind as monomers to the sequence AATGT-AGGTCA. Whereas ROR alpha 1 constitutively activates transcription through this sequence, both isoforms of Rev-erb are inactive. When coexpressed, both Rev-erb isoforms suppress the transcriptional activity of ROR alpha 1. Our data define Rev-erb and ROR/RZR as a family of related receptors with opposing activities on overlapping regulatory networks. |
