| Primary Identifier | MGI:1921772 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 74522 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables histone binding activity. Involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate and positive regulation of DNA methylation-dependent heterochromatin formation. Predicted to be located in cytosol; nuclear matrix; and nucleoplasm. Predicted to be part of heterochromatin. Predicted to be active in nucleus. Is expressed in gonad; heart; nervous system; and skeletal muscle. Used to study Charcot-Marie-Tooth disease axonal type 2Z. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2Z. Orthologous to human MORC2 (MORC family CW-type zinc finger 2). PHENOTYPE: Mice homozygous for a null allele exhibit embryonic lethality around E13.5 and decreased embryo size. Mice homozygous for a null allele activated in neurons exhibit increased brain size, altered brain architecture, and behavioral changes. Heterozygosity for the p.S87L mutation is partially prenatal lethal and leads to Charcot-Marie-Tooth disease-like neuropathies. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
