| First Author | DuBois RN | Year | 1990 |
| Journal | J Biol Chem | Volume | 265 |
| Issue | 31 | Pages | 19185-91 |
| PubMed ID | 1699942 | Mgi Jnum | J:31653 |
| Mgi Id | MGI:79139 | Doi | 10.1016/S0021-9258(17)30642-7 |
| Citation | DuBois RN, et al. (1990) A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence. J Biol Chem 265(31):19185-91 |
| abstractText | Growth factors rapidly induce transcription of a set of genes that encode regulatory proteins, many of which have been identified by cDNA cloning. Here we report the analysis of a cDNA corresponding to a gene induced in mouse 3T3 cells by growth factors and a variety of other extracellular signaling agents. The cDNA encodes a proline-, serine-, and glycine-rich nuclear protein designated Nup475 of 319 amino acids that contains two tandemly repeated cysteine- and histidine-containing sequences (CX8CX5CX3H) suggestive of a novel heavy metal-binding domain. Nup475 produced in Escherichia coli binds zinc. Its mRNA is present in a number of mouse tissues and cell lines, being especially abundant in intestine, thymus, and regenerating liver and in a macrophage cell line stimulated by gamma-interferon. We hypothesize that Nup475 is a regulatory protein with a novel zinc finger structure. |
