| Primary Identifier | MGI:104681 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 15239 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables identical protein binding activity and ubiquitin-modified protein reader activity. Predicted to be involved in several processes, including lysosomal transport; negative regulation of signal transduction; and positive regulation of exosomal secretion. Predicted to act upstream of or within protein transport. Located in cytoplasm. Is expressed in several structures, including branchial arch; central nervous system; limb bud; sensory organ; and spinal component of peripheral nervous system. Orthologous to human HGS (hepatocyte growth factor-regulated tyrosine kinase substrate). PHENOTYPE: Mice homozygous for disruptions in this gene display embryonic lethality during organogenesis with decreased size and no embryo turning. In addition, one allele shows cardia bifida, no foregut formation, failure of chorioallantoic fusion and neural tube,somite and allantois defects. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
