| First Author | Diaz-Marin R | Year | 2021 |
| Journal | Sci Rep | Volume | 11 |
| Issue | 1 | Pages | 15767 |
| PubMed ID | 34344941 | Mgi Jnum | J:314929 |
| Mgi Id | MGI:6817323 | Doi | 10.1038/s41598-021-95064-w |
| Citation | Diaz-Marin R, et al. (2021) Myeloid-resident neuropilin-1 influences brown adipose tissue in obesity. Sci Rep 11(1):15767 |
| abstractText | The beneficial effects of brown adipose tissue (BAT) on obesity and associated metabolic diseases are mediated through its capacity to dissipate energy as heat. While immune cells, such as tissue-resident macrophages, are known to influence adipose tissue homeostasis, relatively little is known about their contribution to BAT function. Here we report that neuropilin-1 (NRP1), a multiligand single-pass transmembrane receptor, is highly expressed in BAT-resident macrophages. During diet-induced obesity (DIO), myeloid-resident NRP1 influences interscapular BAT mass, and consequently vascular morphology, innervation density and ultimately core body temperature during cold exposure. Thus, NRP1-expressing myeloid cells contribute to the BAT homeostasis and potentially its thermogenic function in DIO. |
