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Publication : Genomic imprinting in Dicer1-hypomorphic mice.

First Author  Fukasawa M Year  2006
Journal  Cytogenet Genome Res Volume  113
Issue  1-4 Pages  138-43
PubMed ID  16575173 Mgi Jnum  J:108137
Mgi Id  MGI:3623074 Doi  10.1159/000090825
Citation  Fukasawa M, et al. (2006) Genomic imprinting in Dicer1-hypomorphic mice. Cytogenet Genome Res 113(1-4):138-43
abstractText  To address the function of RNA interference (RNAi) in transcriptional silencing in mammals, we analyzed genomic imprinting in Dicer1-hypomorphic mice, in which Dicer1 expression was significantly reduced. We did not observe any abnormality in the allelic expression of imprinted genes in these mice or their offspring, suggesting that reduced expression of Dicer1 did not significantly affect the maintenance and reprogramming of imprinting.
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