| First Author | Kato S | Year | 1996 |
| Journal | FEBS Lett | Volume | 396 |
| Issue | 2-3 | Pages | 293-7 |
| PubMed ID | 8915006 | Mgi Jnum | J:37188 |
| Mgi Id | MGI:84509 | Doi | 10.1016/0014-5793(96)01119-2 |
| Citation | Kato S, et al. (1996) Differentiation-dependent enhanced expression of protein phosphatase 2Cbeta in germ cells of mouse seminiferous tubules. FEBS Lett 396(2-3):293-7 |
| abstractText | The presence of five distinct isoforms of protein phosphatase 2Cbeta (PP2Cbeta-1 approximately -5) is known. In this study, we demonstrate that the mRNA levels of PP2Cbeta-3, -4 and -5 and PP2Cbeta protein level increased during the course of the first wave of spermatogenesis in neonatal mouse testis. Northern blot and in situ hybridization analyses revealed that PP2Cbeta-3, -4 and -5 were expressed predominantly in pachytene spermatocytes and in more highly differentiated germ cells. The substrate specificity of PP2Cbeta-4 determined with artificial substrates differed from those of PP2Cbeta-3 and -5, suggesting that the difference in the structure of PP2Cbeta-3, -4 and -5 reflect their unique physiological functions in testicular germ cells. |
