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Protein Coding Gene : Svil supervillin
Primary Identifier  MGI:2147319 Organism  mouse, laboratory
Chromosome  18 NCBI Gene Number  225115
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables actin filament binding activity. Acts upstream of or within muscle cell differentiation. Located in several cellular components, including costamere; focal adhesion; and sarcolemma. Is expressed in several structures, including exoccipital bone; gut; meninges; pharyngo-tympanic tube; and skin. Human ortholog(s) of this gene implicated in myofibrillar myopathy 10. Orthologous to human SVIL (supervillin).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit enhanched adhesion and thrombus formation. [provided by MGI curators]
  • synonyms:
  • expressed sequence AU024053,
  • Svil,
  • AU024053,
  • RIKEN cDNA B430302E16 gene,
  • supervillin,
  • MGI:1925796,
  • B430302E16Rik
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