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Protein Coding Gene : Gzma granzyme A
Primary Identifier  MGI:109266 Organism  mouse, laboratory
Chromosome  13 NCBI Gene Number  14938
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables serine-type peptidase activity. Acts upstream of or within response to bacterium. Located in extracellular space and nucleus. Is expressed in thymus primordium. Orthologous to human GZMA (granzyme A).
PHENOTYPE: Homozygotes for a null allele show normal T/NK cell-mediated cytotoxicity, recovery from LCM virus or L. monocytogenes infection, and control of syngeneic tumor growth. Homozygotes for a different null allele show defective CTL cytolysis and increased tumor burden upon challenge with RMAS cells. [provided by MGI curators]
  • synonyms:
  • TSP-1,
  • BLT esterase,
  • Ctla3,
  • TSP1,
  • H factor,
  • serine esterase 1,
  • Gzma,
  • AW494114,
  • MGD-MRK-2233,
  • MGI:2145434,
  • SE1,
  • expressed sequence AW494114,
  • MGD-MRK-2223,
  • granzyme A,
  • Hanukah factor,
  • MGD-MRK-38311,
  • Ctla-3,
  • Hf,
  • cytotoxic T lymphocyte-associated protein 3,
  • MGD-MRK-10699
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