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Publication : Reelin is expressed in the accessory olfactory system, but is not a guidance cue for vomeronasal axons.

First Author  Teillon SM Year  2003
Journal  Brain Res Dev Brain Res Volume  140
Issue  2 Pages  303-7
PubMed ID  12586436 Mgi Jnum  J:82120
Mgi Id  MGI:2451194 Doi  10.1016/s0165-3806(02)00616-8
Citation  Teillon SM, et al. (2003) Reelin is expressed in the accessory olfactory system, but is not a guidance cue for vomeronasal axons. Brain Res Dev Brain Res 140(2):303-7
abstractText  Reelin is an extracellular matrix protein that regulates neuronal migration in the developing cerebral cortex, and axon outgrowth in the hippocampus. In the developing vomeronasal system, Reelin mRNA is expressed in perineural cells near the vomeronasal nerve, as well as in the vomeronasal organ, olfactory epithelium and olfactory and accessory olfactory bulbs, suggesting that it might regulate axon guidance or fasiculation. We tested that hypothesis by crossing reeler mice with VN12-IRES-tau-lacZ mice to investigate the role of reelin. The vomeronasal nerves are indistinguishable in normal and reeler mutant mice, strongly suggesting that Reelin does not provide a guidance cue for vomeronasal axons.
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