| First Author | Shin EJ | Year | 2012 |
| Journal | EMBO Rep | Volume | 13 |
| Issue | 4 | Pages | 339-46 |
| PubMed ID | 22370726 | Mgi Jnum | J:200482 |
| Mgi Id | MGI:5508711 | Doi | 10.1038/embor.2012.3 |
| Citation | Shin EJ, et al. (2012) DeSUMOylating isopeptidase: a second class of SUMO protease. EMBO Rep 13(4):339-46 |
| abstractText | The modification of proteins by small ubiquitin-like modifier (SUMO) is crucial for the regulation of diverse cellular processes. Protein SUMOylation is reversed by isopeptidases, collectively known as deSUMOylases. Only one family of SUMO-specific proteases has been described so far: the sentrin-specific proteases (SENP). Here, we identify and characterize a new deSUMOylase, which we have named DeSI-1 (DeSumoylating Isopeptidase 1). We describe BZEL-a new transcriptional repressor-as substrate of DeSI-1. DeSI-1 catalyses the deSUMOylation, but not the deubiquitination, of BZEL. Furthermore, the SENP substrates PML and DeltaNp63 are not deSUMOylated by DeSI-1, suggesting that SENP and DeSI enzymes recognize different sets of substrates. Together, these data identify a second class of SUMO proteases. |
