| First Author | Tankersley CG | Year | 1994 |
| Journal | Toxicol Lett | Volume | 72 |
| Issue | 1-3 | Pages | 279-89 |
| PubMed ID | 8202942 | Mgi Jnum | J:19137 |
| Mgi Id | MGI:67332 | Doi | 10.1016/0378-4274(94)90039-6 |
| Citation | Tankersley CG, et al. (1994) Ozone-induced inflammation and altered ventilation in genetically susceptible mice: a comparison of acute and subacute exposures. Toxicol Lett 72(1-3):279-89 |
| abstractText | We have examined whether the effects of acute (2 ppm/3 h) and subacute (0.3 ppm/72 h) ozone (O3) exposures on airways are mutually predictive. Inbred C57BL/6J (susceptible) and C3H/HeJ (resistant) mice are differentially responsive to inflammation induced by the 2 exposures. Breeding experiments and cosegregation analysis indicated that 2 separate genes control inflammatory responses: Inf (acute), Inf-2 (subacute). The genetic model was also used to examine the effects of both exposures on the magnitude and pattern of breathing. Results imply that mechanisms that control susceptibility to the 2 exposures are not the same, and that one response is not necessarily predictive of the other. |
