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Protein Coding Gene : Ccl2 C-C motif chemokine ligand 2

Primary Identifier  MGI:98259 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  20296
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables CCR2 chemokine receptor binding activity and cytokine activity. Involved in several processes, including cellular response to cytokine stimulus; positive regulation of leukocyte chemotaxis; and regulation of macromolecule biosynthetic process. Acts upstream of or within response to bacterium and response to wounding. Located in extracellular space. Is expressed in several structures, including heart; intestine; mandible; nervous system; and retina. Used to study age related macular degeneration. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; aggressive periodontitis; autoimmune disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple). Orthologous to several human genes including CCL2 (C-C motif chemokine ligand 2).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit defective macrophage recruitment, abnormal choroid morphology, photoreceptor degeneration, and altered response to injury, infection, alcohol, and a high fat diet. [provided by MGI curators]
  • synonyms:
  • small inducible gene JE,
  • C-C motif chemokine ligand 2,
  • MCP1,
  • MCAF,
  • Scya2,
  • SMC-CF,
  • HC11,
  • MGD-MRK-14413,
  • MGD-MRK-14333,
  • MCP-1,
  • monocyte chemoattractant protein-1,
  • MGI:2144120,
  • Ccl2,
  • Sigje,
  • expressed sequence AI323594,
  • monocyte chemotactic protein,
  • AI323594,
  • small inducible cytokine A2

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

4 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

0 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For