| Type | MGI:General | Description | symptomatic homozygotes exhibit a 60% increase in the number of myenetric neurons/ganglion in the proximal colon along with a 66% increase in the number of neurons/ganglion in the distal colon; similar changes are observed in asymptomatic homozygotes in addition, homozygotes show a 41% increase in NADPH diaphorase-stained inhibitory myenteric neurons/ganglion in proximal colon along with a 130% increase in distal colon in contrast, homozygotes display a 22% decrease in the number of neurons/ganglion in the distal ileum (with no apparent changes in proximal ileum), and a 58% decrease in NADPH-stained inhibitory neurons/ganglion in the distal ileum |
