Primary Identifier | MGI:2651874 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 230784 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables GDP-dissociation inhibitor activity and PH domain binding activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of TORC1 signaling; and negative regulation of translation in response to endoplasmic reticulum stress. Acts upstream of or within several processes, including glucose import; positive regulation of lipophagy; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Part of TORC2 complex and nucleotide-activated protein kinase complex. Is expressed in central nervous system and retina. Orthologous to human SESN2 (sestrin 2). PHENOTYPE: Mouse lung fibroblasts homozgyous for a gene trap allele exhibit increased cellular sensitivity to hydrogen peroxide, decreased proliferation, and increased apoptosis. [provided by MGI curators] |