Primary Identifier | MGI:2388632 | Allele Type | Targeted |
Attribute String | Null/knockout, Reporter | Gene | Fzd3 |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The coding regions of the exons 1 and 2 were replaced with a cassette containing lacZ and neo genes. The deleted region encoded the amino terminal signal sequence and a conserved extracellular domain that has been previously been shown to be involved wiht Wnt binding. The expression pattern of beta-galactosidase replicated that of the endogenous gene. |