| Primary Identifier | IPR030034 | Type | Family |
| Short Name | Orai-2 |
| description | Orai1 is a pore-forming calcium release-activated calcium (CRAC) channel subunit composed of four transmembrane domains []. Paralogues Orai2 and Orai3 have also been shown to be capable of forming CRAC channels and share Orai1 membrane topology. In these experiments, Orai-1, -2, and -3 channels were similarly inhibited by extracellular Ca2+. Orai3 channels seems to differ from Orai1 and -2 in being relatively resistant to the process of Ca2+ depotentiation []. However, the physiological roles of Orai2 and Orai3 in vivo are currently not well understood [].This entry represents Orai2. |
