| Primary Identifier | IPR001252 | Type | Active_site |
| Short Name | Malate_DH_AS |
| description | Malate dehydrogenase () (MDH) []catalyzes the interconversionof malate to oxaloacetate utilizing the NAD/NADH cofactor system. The enzymeparticipates in the citric acid cycle and exists in allaerobics organisms.While prokaryotic organisms contains a single form of MDH, in eukaryotic cellsthere are two isozymes: one which is located in the mitochondrial matrix andthe other in the cytoplasm. Fungi and plants also harbor a glyoxysomal formwhich functions in the glyoxylate pathway. In plants chloroplast there is anadditional NADP-dependent form of MDH () which is essential forboth the universal C3 photosynthesis (Calvin) cycle and the more specialisedC4 cycle.The pattern for this enzyme includestwo residues involved in the catalytic mechanism []: an aspartic acid whichis involved in a proton relay mechanism, and an arginine which binds thesubstrate. |
