| Primary Identifier | IPR035711 | Type | Family |
| Short Name | Complement_C3-like |
| description | This entry includes complement C3, a major component in the both the classical and alternative complement activation pathways. C3 is cleaved into two chains, known as alpha (C3a) and beta (C3b) by C3 convertases. C3b binds to cell surface carbohydrates or immune aggregates []. C3a is an anaphylatoxin and mediator of a localized inflammatory response, acting as a chemoattractant for neutrophils []. Both alpha and beta chains can be further processed to generate fragments with other properties; for example, C3-beta-c is also a chemoattractant [].This entry also includes complement C3-like proteins from snake venoms, such as AVF-1 and -2 from Austrelaps superbus, which have been shown to activate human complement Factor B in the presence of Factor D and Mg2+, and deplete the complement activity in human and guinea pig serum []. |
