| First Author | Starlets D | Year | 2006 |
| Journal | Blood | Volume | 107 |
| Issue | 12 | Pages | 4807-16 |
| PubMed ID | 16484589 | Mgi Jnum | J:132865 |
| Mgi Id | MGI:3777063 | Doi | 10.1182/blood-2005-11-4334 |
| Citation | Starlets D, et al. (2006) Cell-surface CD74 initiates a signaling cascade leading to cell proliferation and survival. Blood 107(12):4807-16 |
| abstractText | CD74 is an integral membrane protein that was thought to function mainly as an MHC class II chaperone. However, CD74 was recently shown to have a role as an accessory-signaling molecule. Our studies demonstrated that CD74 regulates B-cell differentiation by inducing a pathway leading to the activation of transcription mediated by the NF-kappaB p65/RelA homodimer and its coactivator, TAF(II)105. Here, we show that CD74 stimulation with anti-CD74 antibody leads to an induction of a signaling cascade resulting in NF-kappaB activation, entry of the stimulated cells into the S phase, elevation of DNA synthesis, cell division, and augmented expression of BCL-X(L). These studies therefore demonstrate that surface CD74 functions as a survival receptor. |
