| First Author | Wu JM | Year | 2015 |
| Journal | Circ Res | Volume | 116 |
| Issue | 4 | Pages | 633-41 |
| PubMed ID | 25398235 | Mgi Jnum | J:252820 |
| Mgi Id | MGI:6098924 | Doi | 10.1161/CIRCRESAHA.116.304564 |
| Citation | Wu JM, et al. (2015) Circulating cells contribute to cardiomyocyte regeneration after injury. Circ Res 116(4):633-41 |
| abstractText | RATIONALE: The contribution of bone marrow-borne hematopoietic cells to the ischemic myocardium has been documented. However, a pivotal study reported no evidence of myocardial regeneration from hematopoietic-derived cells. The study did not take into account the possible effect of early injury-induced signaling as the test mice were parabiotically paired to partners immediately after surgery-induced myocardial injury when cross-circulation has not yet developed. OBJECTIVE: To re-evaluate the role of circulating cells in the injured myocardium. METHODS AND RESULTS: By combining pulse-chase labeling and parabiosis model, we show that circulating cells derived from the parabiont expressed cardiac-specific markers in the injured myocardium. Genetic fate mapping also revealed that circulating hematopoietic cells acquired cardiac cell fate by means of cell fusion and transdifferentiation. CONCLUSIONS: These results suggest that circulating cells participate in cardiomyocyte regeneration in a mouse model of parabiosis when the circulatory system is fully developed before surgery-induced heart injury. |
