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Publication : Wnt signaling: an essential regulator of cardiovascular differentiation, morphogenesis and progenitor self-renewal.

First Author  Cohen ED Year  2008
Journal  Development Volume  135
Issue  5 Pages  789-98
PubMed ID  18263841 Mgi Jnum  J:132123
Mgi Id  MGI:3775158 Doi  10.1242/dev.016865
Citation  Cohen ED, et al. (2008) Wnt signaling: an essential regulator of cardiovascular differentiation, morphogenesis and progenitor self-renewal. Development 135(5):789-98
abstractText  Emerging evidence indicates that Wnt signaling regulates crucial aspects of cardiovascular biology (including cardiac morphogenesis, and the self-renewal and differentiation of cardiac progenitor cells). The ability of Wnt signaling to regulate such diverse aspects of cardiovascular development rests on the multifarious downstream and tangential targets affected by this pathway. Here, we discuss the roles for Wnt signaling in cardiac and vascular development, and focus on the emerging role of Wnt signaling in cardiovascular morphogenesis and progenitor cell self-renewal.
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