| Primary Identifier | MGI:3525201 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 240087 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable histone reader activity. Predicted to be involved in several processes, including DNA replication checkpoint signaling; positive regulation of transcription initiation by RNA polymerase II; and protein localization to site of double-strand break. Predicted to act upstream of or within DNA repair. Located in chromosome. Is expressed in cerebral cortex ventricular layer; diencephalon lateral wall ventricular layer; midbrain ventricular layer; olfactory lobe; and telencephalon ventricular layer. Orthologous to human MDC1 (mediator of DNA damage checkpoint 1). PHENOTYPE: Homozygous mutant mice are smaller and display increased susceptibility to ionizing radiation, male infertility, T and B cell abnormalities, and increased genomic instability. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
