| First Author | Goulet JL | Year | 1994 |
| Journal | Proc Natl Acad Sci U S A | Volume | 91 |
| Issue | 26 | Pages | 12852-6 |
| PubMed ID | 7809134 | Mgi Jnum | J:68714 |
| Mgi Id | MGI:1933116 | Doi | 10.1073/pnas.91.26.12852 |
| Citation | Goulet JL, et al. (1994) Altered inflammatory responses in leukotriene-deficient mice. Proc Natl Acad Sci U S A 91(26):12852-6 |
| abstractText | Leukotrienes have been implicated in the regulation of immune responses, including inflammation and immediate hypersensitivity reactions. Here, we describe the phenotypic analysis of leukotriene-deficient mice generated by inactivation of the 5-lipoxygenase (5LO) gene. These 5LO(-/-) mice were unable to synthesize detectable levels of leukotrienes and were more resistant to lethal anaphylaxis induced by platelet-activating factor. The intensity of an acute inflammatory response induced by arachidonic acid was similar in 5LO(-/-) mice and controls. However, the response in 5LO(-/-) mice, but not in controls, could be virtually eliminated by a cyclooxygenase inhibitor. These data suggest that inflammatory responses are modulated by arachidonic acid metabolites through a variety of interconnected mechanisms. This has important implications for understanding the early events of an inflammatory response and for designing drugs for use in therapeutic intervention. |
