Primary Identifier | MGI:1924050 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 76800 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables cysteine-type deubiquitinase activity. Predicted to be involved in regulation of apoptotic process. Predicted to act upstream of or within cell differentiation and proteolysis. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain; eye; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human USP42 (ubiquitin specific peptidase 42). PHENOTYPE: Mice homozygous for a null allele exhibit fecundity and behavioral abnormalities, hyperactivity, increased T cell number, abnormal lens morphology, and cataracts. Males display oligozoospermia and testis degeneration. [provided by MGI curators] |