| First Author | Liu QR | Year | 1992 |
| Journal | FEBS Lett | Volume | 305 |
| Issue | 2 | Pages | 110-4 |
| PubMed ID | 1618338 | Mgi Jnum | J:1378 |
| Mgi Id | MGI:49905 | Doi | 10.1016/0014-5793(92)80875-h |
| Citation | Liu QR, et al. (1992) Cloning and expression of a glycine transporter from mouse brain. FEBS Lett 305(2):110-4 |
| abstractText | We have isolated a cDNA clone from a mouse brain library encoding the glycine transporter (GLYT). Xenopus oocytes injected with a synthetic mRNA accumulated [3h]glycine to levels of up to 80-fold above control values. The uptake was specific for glycine and dependent on the presence of Na+ and Cl- in the medium. The cDNA sequence predicts a highly hydrophobic protein of 633 amino acids with 12 potential transmembrane helices. The predicted amino acid sequence has 40-45% identity to the GABA, noradrenaline, serotonin and dopamine transporters. This implies that all of these neurotransmitter transporters may have evolved from a common ancestral gene that diverged into the GABA, glycine and catecholamine subfamilies at nearly the same time. |
