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Protein Coding Gene : Emc3 ER membrane protein complex subunit 3
Primary Identifier  MGI:1913337 Organism  mouse, laboratory
Chromosome  6 NCBI Gene Number  66087
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of EMC complex. Is expressed in lung. Orthologous to human EMC3 (ER membrane protein complex subunit 3).
PHENOTYPE: Mice homozygous for an inducible conditional allele exhibit thin retinal outer nuclear layer with retinal degeneration and reduced Rho trafficking to the outer segment. [provided by MGI curators]
  • synonyms:
  • 0610039A15Rik,
  • RIKEN cDNA 0610039A15 gene,
  • AW260416,
  • AI225901,
  • Emc3,
  • ER membrane protein complex subunit 3,
  • Tmem111,
  • expressed sequence AW260416,
  • transmembrane protein 111,
  • MGI:2141673,
  • MGI:1353660,
  • EST AI225901
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Features --> Cross References

Genome

Sequence Feature Displayer

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1 Involved In Mutations

Trail: ProteinCodingGene

0 Strain

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

5 Pathways

Trail: ProteinCodingGene

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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