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Protein Coding Gene : Fbxw11 F-box and WD-40 domain protein 11

Primary Identifier  MGI:2144023 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  103583
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables ubiquitin-protein transferase activity. Contributes to ubiquitin protein ligase activity. Involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of non-canonical NF-kappaB signal transduction; and positive regulation of circadian rhythm. Located in cytosol and nucleus. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including genitourinary system and yolk sac. Orthologous to human FBXW11 (F-box and WD repeat domain containing 11).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic growth arrest and complete embryonic lethality before E10.5. [provided by MGI curators]
  • synonyms:
  • Fbxw11,
  • RIKEN cDNA 2310065A07 gene,
  • BTRC2,
  • F-box and WD-40 domain protein 1B,
  • expressed sequence AA536858,
  • AA536858,
  • mKIAA0696,
  • F-box and WD-40 domain protein 11,
  • BTRCP2,
  • MGI:1919630,
  • HOS,
  • Fbxw1b,
  • 2310065A07Rik

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

48 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For