| First Author | Laitinen J | Year | 1995 |
| Journal | J Cell Biochem | Volume | 58 |
| Issue | 4 | Pages | 490-8 |
| PubMed ID | 7593271 | Mgi Jnum | J:31101 |
| Mgi Id | MGI:78572 | Doi | 10.1002/jcb.240580412 |
| Citation | Laitinen J, et al. (1995) U2-snRNP B protein gene is an early growth-inducible gene. J Cell Biochem 58(4):490-8 |
| abstractText | In this work we isolated mouse U2-snRNP-specific b clones and analysed the expression of the mouse U2-snRNP-specific b and U1-snRNP-specific 70K genes in NIH-3T3 fibroblasts. Stimulation of growth-arrested NIH-3T3 cells with serum was found to evoke a rapid increase in the amount of cytoplasmic b and 70K mRNAs. These increases in mRNA did not require de novo protein synthesis. Moreover, the inhibition of protein synthesis by cycloheximide caused a superinduction in the amounts of the U1-snRNP-specific 70K transcripts. We also found that c-Ha-rasVal12 oncogene-transformed NIH-3T3 cells have higher levels of the b and 70K mRNAs than the normal 3T3 cells. These data imply that the b and 70K are early growth response genes, and their enhanced expression might be of significance in the processing of pre-mRNAs into mature mRNAs. |
