| First Author | Budd RC | Year | 1994 |
| Journal | Semin Immunol | Volume | 6 |
| Issue | 1 | Pages | 43-8 |
| PubMed ID | 8167306 | Mgi Jnum | J:19056 |
| Mgi Id | MGI:67268 | Doi | 10.1006/smim.1994.1007 |
| Citation | Budd RC, et al. (1994) Parallels in T lymphocyte development between lpr and normal mice. Semin Immunol 6(1):43-8 |
| abstractText | The unusual phenotype and function of lpr T cell subsets has considerably aided the determination of various stages in normal T lymphocyte development through the identification of parallel populations. This has included the description of memory T cells that express high levels of CD44. Lpr mature (CD4+ and CD8+) T cells are all CD44hi and produce large amounts of several cytokines, in contrast to normal murine peripheral T cells. However, the minor CD44hi subset of normal memory T cells produces similarly high levels of cytokines. The expression of intermediate density surface T cell antigen receptor (TCR)-alpha beta by lpr CD4-, CD8- (CD4-8-) cells guided the identification of a minor subset of Heat Stable Antigen--normal CD4-8- thymocytes that also expresses TCR-alpha beta. The unresponsiveness of lpr CD4-8- T cells correlates closely with their absence of CD2 expression. This is paralleled in normal mice by CD2- and CD2+ subsets of thymocytes and gut lymphocytes in which the proliferative capacity also segregates with CD2 expression. Finally, lpr CD4-8- T cells bear many similarities to anergic T cells, including high expression of p59fyn, lack of IL-2 production, and recovery of function following induction of cell cycling in the presence of IL-2. The developmental block in lpr CD4-8- T cells has therefore provided considerable insight into normal T cell development and function. |
