| First Author | Vito P | Year | 1996 |
| Journal | Science | Volume | 271 |
| Issue | 5248 | Pages | 521-5 |
| PubMed ID | 8560270 | Mgi Jnum | J:33763 |
| Mgi Id | MGI:81240 | Doi | 10.1126/science.271.5248.521 |
| Citation | Vito P, et al. (1996) Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3. Science 271(5248):521-5 |
| abstractText | Two apoptosis-linked genes, named ALG-2 and ALG-3, were identified by means of a functional selection strategy. ALG-2 codes for a Ca(2+)-binding protein required for T cell receptor-, Fas-, and glucocorticoid-induced cell death. ALG-3, a partial complementary DNA that is homologous to the familial Alzheimer's disease gene STM2, rescues a T cell hybridoma from T cell receptor- and Fas-induced apoptosis. These findings suggest that ALG-2 may mediate Ca(2+)-regulated signals along the death pathway and that cell death may play a role in Alzheimer's disease. |
