| First Author | Selvaraj D | Year | 2015 |
| Journal | Cancer Cell | Volume | 27 |
| Issue | 6 | Pages | 780-96 |
| PubMed ID | 26058077 | Mgi Jnum | J:222917 |
| Mgi Id | MGI:5646040 | Doi | 10.1016/j.ccell.2015.04.017 |
| Citation | Selvaraj D, et al. (2015) A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain. Cancer Cell 27(6):780-96 |
| abstractText | Cancer pain is a debilitating disorder and a primary determinant of the poor quality of life. Here, we report a non-vascular role for ligands of the Vascular Endothelial Growth Factor (VEGF) family in cancer pain. Tumor-derived VEGF-A, PLGF-2, and VEGF-B augment pain sensitivity through selective activation of VEGF receptor 1 (VEGFR1) expressed in sensory neurons in human cancer and mouse models. Sensory-neuron-specific genetic deletion/silencing or local or systemic blockade of VEGFR1 prevented tumor-induced nerve remodeling and attenuated cancer pain in diverse mouse models in vivo. These findings identify a therapeutic potential for VEGFR1-modifying drugs in cancer pain and suggest a palliative effect for VEGF/VEGFR1-targeting anti-angiogenic tumor therapies. |
