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Protein Coding Gene : Kat2a K(lysine) acetyltransferase 2A

Primary Identifier  MGI:1343101 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  14534
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables DNA-binding transcription factor binding activity; chromatin binding activity; and histone acetyltransferase activity. Involved in several processes, including long-term memory; positive regulation of macromolecule biosynthetic process; and regulation of regulatory T cell differentiation. Acts upstream of or within several processes, including brain development; chordate embryonic development; and positive regulation of gluconeogenesis. Located in mitotic spindle and nucleus. Part of ATAC complex and SAGA complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and hemolymphoid system gland. Orthologous to human KAT2A (lysine acetyltransferase 2A).
PHENOTYPE: Homozygotes for targeted null mutations exhibit poorly developed yolk sac blood vessels, retarded growth, absence of dorsal mesoderm lineages, failure to form somites, and lethality between embryonic days 9.5-11.5. [provided by MGI curators]
  • synonyms:
  • GCN5 general control of amino acid synthesis-like 2 (yeast),
  • RIKEN cDNA 1110051E14 gene,
  • Gcn5,
  • expressed sequence AW212720,
  • Kat2a,
  • MGI:1924162,
  • Gcn5l2,
  • 1110051E14Rik,
  • general control of amino acid synthesis-like 2 yeast),
  • PCAF-B/GCN5,
  • K(lysine) acetyltransferase 2A,
  • AW212720,
  • MGI:2144513

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

3 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

18 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For