| Primary Identifier | MGI:1338009 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 16370 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable insulin receptor binding activity and phosphatidylinositol 3-kinase binding activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in membrane. Predicted to be active in cytosol and plasma membrane. Is expressed in several structures, including alimentary system; brain; branchial arch; eye; and genitourinary system. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 9 and lung cancer. Orthologous to human IRS4 (insulin receptor substrate 4). PHENOTYPE: Homozygotes for a targeted null mutation exhibit a 10% reduction in male adult size, slightly impaired oral glucose tolerance, and decreased reproductive ability. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
