| Primary Identifier | MGI:1261827 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 13435 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables S-adenosylmethionine-dependent methyltransferase activity; chromatin binding activity; and nucleic acid binding activity. Involved in autosome genomic imprinting and negative regulation of gene expression via chromosomal CpG island methylation. Acts upstream of or within several processes, including cellular response to bisphenol A; epigenetic regulation of gene expression; and negative regulation of transcription by RNA polymerase II. Located in chromosome; cytoplasm; and nucleus. Part of heterochromatin. Is expressed in several structures, including brain; early conceptus; genitourinary system; limb mesenchyme; and sensory organ. Human ortholog(s) of this gene implicated in Tatton-Brown-Rahman syndrome; hematologic cancer (multiple); and stomach cancer. Orthologous to human DNMT3A (DNA methyltransferase 3 alpha). PHENOTYPE: Homozygotes for a targeted null mutation become runted and die around four weeks of age. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
