| First Author | Albrecht U | Year | 1997 |
| Journal | Cell | Volume | 91 |
| Issue | 7 | Pages | 1055-64 |
| PubMed ID | 9428527 | Mgi Jnum | J:44820 |
| Mgi Id | MGI:1101366 | Doi | 10.1016/s0092-8674(00)80495-x |
| Citation | Albrecht U, et al. (1997) A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light. Cell 91(7):1055-64 |
| abstractText | A mouse gene, mper1, having all the properties expected of a circadian clock gene, was reported recently. This gene is expressed in a circadian pattern in the suprachiasmatic nucleus (SCN). mper1 maintains this pattern of circadian expression in constant darkness and can be entrained to a new light/dark cycle. Here we report the isolation of a second mammalian gene, mper2, which also has these properties and greater homology to Drosophila period. Expression of mper1 and mper2 is overlapping but asynchronous by 4 hr. mper1, unlike period and mper2, is expressed rapidly after exposure to light at CT22. It appears that mper1 is the pacemaker component which responds to light and thus mediates photic entrainment. |
