| First Author | Liu J | Year | 2010 |
| Journal | Proc Natl Acad Sci U S A | Volume | 107 |
| Issue | 47 | Pages | 20494-9 |
| PubMed ID | 21059917 | Mgi Jnum | J:166594 |
| Mgi Id | MGI:4848231 | Doi | 10.1073/pnas.1007001107 |
| Citation | Liu J, et al. (2010) Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell survival via PDK1. Proc Natl Acad Sci U S A 107(47):20494-9 |
| abstractText | Three-amino-acid-loop-extension (TALE) homeodomain proteins including Meis and Pbx families are generally recognized for their roles in growth and differentiation during vertebrate embryogenesis and tumorigenesis. Whereas genetic studies indicate that Pbx1 regulates the development and function of insulin-producing pancreatic beta-cells, the role of Meis family members in beta-cells is still unknown. Here we show that Meis3 is abundantly expressed in pancreatic islets and beta-cells and that it regulates beta-cell survival. We further identify the 3-phosphoinositide-dependent protein kinase 1 (PDK1), a well-known kinase involved in the PI3K-Akt signaling pathway, as a direct Meis3 target, which mediates its role in beta-cell survival. This regulatory module appears to function broadly as we also identify Meis3 regulation of cell survival and PDK1 expression in ovarian carcinoma cells, suggesting a unique function for Meis3 beyond the traditional roles for TALE homeodomain factors during embryogenesis. |
