| Primary Identifier | MGI:6400423 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Dpp4 |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | CRISPR/Cas9 technology introduced two amino acid changes, an alanine to leucine substitution at amino acid 288 (A288L) in exon 10 and a threonine to arginine substitution at amino acid 330 (T330R) in exon 11. These two changes match the human sequence, making mice susceptible to Middle East respiratory syndrome coronavirus infection and replication. |
