First Author | Goffin D | Year | 2014 |
Journal | Nat Neurosci | Volume | 17 |
Issue | 6 | Pages | 804-6 |
PubMed ID | 24777420 | Mgi Jnum | J:212933 |
Mgi Id | MGI:5582548 | Doi | 10.1038/nn.3710 |
Citation | Goffin D, et al. (2014) Cellular origins of auditory event-related potential deficits in Rett syndrome. Nat Neurosci 17(6):804-6 |
abstractText | Dysfunction in sensory information processing is a hallmark of many neurological disorders, including autism spectrum disorders, schizophrenia and Rett syndrome (RTT). Using mouse models of RTT, a monogenic disorder caused by mutations in MECP2, we found that the large-scale loss of MeCP2 from forebrain GABAergic interneurons led to deficits in auditory event-related potentials and seizure manifestation, whereas the restoration of MeCP2 in specific classes of interneurons ameliorated these deficits. |