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Comment :

Type  MGI:General Description  non-ovariectomized homozygotes show normal osteoclastogenesis and osteoclast bone-resorbing activity, as shown by normal osteoclast surface and normal number of osteoclast precursors (CFU-GM) in the bone marrow however, unlike ovariectomized wild-type mice, homozygotes fail to exhibit increased numbers of CFU-GM in the bone marrow following estrogen depletion