| Primary Identifier | MGI:1206039 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 18096 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within several processes, including enteroendocrine cell differentiation; regulation of axon extension; and regulation of oligodendrocyte differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; future brain; and gut. Orthologous to human NKX6-1 (NK6 homeobox 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit neonatal lethality, abnormal neuron specification, decreased motor neuron number, and reduced pancreatic beta cell number and insulin secretion. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
