| Primary Identifier | MGI:88348 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 12527 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables integrin binding activity. Involved in several processes, including fusion of sperm to egg plasma membrane involved in single fertilization; myoblast fusion involved in skeletal muscle regeneration; and paranodal junction assembly. Acts upstream of or within negative regulation of cell population proliferation. Located in external side of plasma membrane and extracellular exosome. Is expressed in several structures, including alimentary system; heart; nervous system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in prostate adenocarcinoma. Orthologous to human CD9 (CD9 molecule). PHENOTYPE: Females homozygous for targeted null mutations are infertile due to lack of sperm-egg fusion. Mice heterozygous for conditional alleles activated in pancreatic cells exhibit reduced tumor growth in a pancreatic tumor mouse model. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
