| First Author | Miyado K | Year | 2000 |
| Journal | Science | Volume | 287 |
| Issue | 5451 | Pages | 321-4 |
| PubMed ID | 10634791 | Mgi Jnum | J:59402 |
| Mgi Id | MGI:1351541 | Doi | 10.1126/science.287.5451.321 |
| Citation | Miyado K, et al. (2000) Requirement of CD9 on the egg plasma membrane for fertilization. Science 287(5451):321-4 |
| abstractText | CD9 is an integral membrane protein associated with integrins and other membrane proteins. Mice lacking CD9 were produced by homologous recombination. Both male and female CD9-/- mice were born healthy and grew normally. However, the litter size from CD9-/- females was less than 2% of that of the wild type. In vitro fertilization experiments indicated that the cause of this infertility was due to the failure of sperm-egg fusion. When sperm were injected into oocytes with assisted microfertilization techniques, however, the fertilized eggs developed to term. These results indicate that CD9 has a crucial role in sperm-egg fusion. |
