| Primary Identifier | IPR001100 | Type | Family |
| Short Name | Pyr_nuc-diS_OxRdtase |
| description | The pyridine nucleotide-disulphide reductases (PNDR) use the isoalloxazinering of FAD to shuttle reducing equivalents from NAD(P)H to a Cys residuethat is usually a part of a redox-active disulphide bridge. In a secondstep, the reduced disulphide reduces the substrate. On the basis of sequence and structural similarities [], PNDR can be categorised into 2groups.Class I includes glutathione reductase, trypanothione reductase,lipoamide dehydrogenase and mercuric reductase. They cover a wide range ofcatalytic functions: glutathione reductase ensures that the cell has enough reduced glutathione to maintain protein thiol groups in the reducedstate []; trypanothione reductase carries out the analogous reaction in trypanosomal cells (trypanothione is an analogue of glutathione) []; lipoamide dehydrogenase, the E3 component of alpha-ketoacid dehydrogenasemultienzyme complex, oxidises the dihydrolypoyl groups of lipoate acyltransferase, and so couples glycolysis to the tricarboxylic acid cycle []; and mercuric reductase enables bacteria to detoxify the mercuric ionby reducing it to elemental mercury, which evaporates from the cell []. |
