| Primary Identifier | MGI:2388378 | Allele Type | Targeted |
| Attribute String | Inserted expressed sequence | Gene | Pax3 |
| Transmission | Germline | Strain of Origin | 129X1/SvJ |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | To replicate t(2;13), a chromosomal transloction associated with the pediatric disease alveolar rhabdomyosarcoma, a sequence fragment from a PAX3-FOXO1A fusion cDNA was inserted at the endogenous locus via homologous recombination. The last 50 bp of the endogenous exon 7 were replaced with related PAX3 sequence and a 3' portion of FOXO1A. Various analyses indicated low levels of expression of the knock-in allele. |
