| First Author | Takao T | Year | 1995 |
| Journal | Brain Res | Volume | 688 |
| Issue | 1-2 | Pages | 219-22 |
| PubMed ID | 8542313 | Mgi Jnum | J:28071 |
| Mgi Id | MGI:75701 | Doi | 10.1016/0006-8993(95)00561-4 |
| Citation | Takao T, et al. (1995) Corticotropin-releasing factor treatment upregulates interleukin-1 receptors in the mouse pituitary: reversal by dexamethasone. Brain Res 688(1-2):219-22 |
| abstractText | Intraperitoneal injection of rat/human corticotropin-releasing factor (CRF) (40 micrograms/kg/0.2 ml of saline) resulted in a dramatic increase in specific iodine-125-labeled human interleukin-1 alpha ([125I]IL-1 alpha) binding in the male C57BL/6 mouse pituitary at 2 and 6 h after the injection although it did not affect [125I]IL-1 alpha binding in the mouse hippocampus, spleen and testis at any time after the injection. [125I]IL-1 alpha binding was unchanged at 2 h following dexamethasone (DEX) treatment (1 mg/kg/0.2 ml of 4% ethanol-saline) in the mouse pituitary and the hippocampus. In contrast, DEX inhibited CRF-induced upregulation of IL-1 receptors in the pituitary at 2 h after the injection. These data demonstrate complex interactions between CRF and DEX on IL-1 receptors during stress. |
