| Primary Identifier | IPR017729 | Type | Family |
| Short Name | ATPase_T6SS_ClpV1 |
| description | The type VI secretion system (T6SS) is a supra-molecular bacterial complex that resembles phage tails. It is a toxin delivery systems which fires toxins into target cells upon contraction of its TssBC sheath []. Thirteen essential core proteins are conserved in all T6SSs: the membrane associated complex TssJ-TssL-TssM, the baseplate proteins TssE, TssF, TssG, and TssK, the bacteriophage-related puncturing complex composed of the tube (Hcp), the tip/puncturing device VgrG, and the contractile sheath structure (TssB and TssC). Finally, the starfish-shaped dodecameric protein, TssA, limits contractile sheath polymerization at its distal part when TagA captures TssA []. ClpV is an AAA(+) ATPase that disassembles the type VI secretion system contracted sheath, which resets the systems for reassembly of an extended sheath that is ready to fire again []. The ClpV proteins are most similar to ClpB proteins within the Hsp100/Clp family, but cluster in a separate phylogenetic tree with a remarkable distance to ClpB []. However, this entry also includes ClpB from Yersinia enterocolitica []. |
